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dc.contributor.authorKonstantinidis, Ioannis
dc.contributor.authorSætrom, Pål
dc.contributor.authorMjelle, Robin
dc.contributor.authorNedoluzhko, Artem
dc.contributor.authorRobledo, Diego
dc.contributor.authorFernandes, Jorge Manuel de Oliveira
dc.date.accessioned2020-07-02T08:30:36Z
dc.date.available2020-07-02T08:30:36Z
dc.date.created2020-04-08T05:08:14Z
dc.date.issued2020
dc.identifier.citationKonstantinidis, I., Sætrom, P., Mjelle, R., Nedoluzhko, A., Robledo, D. & Fernandes, J. M. de O. (2020). Major gene expression changes and epigenetic remodelling in Nile tilapia muscle after just one generation of domestication. Epigenetics. doi:en_US
dc.identifier.issn1559-2308
dc.identifier.urihttps://hdl.handle.net/11250/2660427
dc.description.abstractThe historically recent domestication of fishes has been essential to meet the protein demands of a growing human population. Selection for traits of interest during domestication is a complex process whose epigenetic basis is poorly understood. Cytosine hydroxymethylation is increasingly recognized as an important DNA modification involved in epigenetic regulation. In the present study, we investigated if hydroxymethylation plays a role in fish domestication and demonstrated for the first time at a genome-wide level and single nucleotide resolution that the muscle hydroxymethylome changes after a single generation of Nile tilapia (Oreochromis niloticus, Linnaeus) domestication. The overall decrease in hydroxymethylcytosine levels was accompanied by the downregulation of 2015 genes in fish reared in captivity compared to their wild progenitors. In contrast, several myogenic and metabolic genes that can affect growth potential were upregulated. There were 126 differentially hydroxymethylated cytosines between groups, which were not due to genetic variation; they were associated with genes involved in immune-, growth- and neuronal-related pathways. Taken together, our data unveil a new role for DNA hydroxymethylation in epigenetic regulation of fish domestication with impact in aquaculture and implications in artificial selection, environmental adaptation and genome evolution.en_US
dc.language.isoengen_US
dc.publisherTaylor & Francis Groupen_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.no*
dc.titleMajor gene expression changes and epigenetic remodelling in Nile tilapia muscle after just one generation of domesticationen_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.description.versionpublishedVersionen_US
dc.rights.holder© 2020 The Author(s)en_US
dc.subject.nsiVDP::Matematikk og Naturvitenskap: 400::Basale biofag: 470::Genetikk og genomikk: 474en_US
dc.subject.nsiVDP::Landbruks- og Fiskerifag: 900::Fiskerifag: 920::Akvakultur: 922en_US
dc.source.pagenumber16en_US
dc.source.journalEpigeneticsen_US
dc.identifier.doi10.1080/15592294.2020.1748914
dc.identifier.cristin1805606
dc.relation.projectEC/H2020/683210en_US
dc.relation.projectResearch Council of Norway: 250548/F20en_US
dc.description.localcodePaid Open Accessen_US


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