Browsing Nord Open Research Archive by Author "Pomponi, Shirley A."
Now showing items 1-2 of 2
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Breakthrough in marine invertebrate cell culture : Sponge cells divide rapidly in improved nutrient medium
Conkling, Megan; Hesp, Kylie; Munroe, Stephanie; Sandoval, Kenneth; Martens, Dirk E.; Sipkema, Detmer; Wijffels, Rene Hubertus; Pomponi, Shirley A. (Peer reviewed; Journal article, 2019)Sponges (Phylum Porifera) are among the oldest Metazoa and considered critical to understanding animal evolution and development. They are also the most prolific source of marine-derived chemicals with pharmaceutical ... -
CRISPR/Cas12a-mediated gene editing in Geodia barretti sponge cell culture
Hesp, Kylie; Alvarez, John L. Flores; Alexandru, Ana-Maria; van der Linden, Jip; Martens, Dirk E.; Wijffels, Rene Hubertus; Pomponi, Shirley A. (Peer reviewed; Journal article, 2020)Sponges and their associated microorganisms are the most prolific source of marine natural products, and many attempts have been made at creating a marine sponge cell line to produce these products efficiently. However, ...