dc.contributor.author | Penaforte-Saboia, Jaquellyne G | |
dc.contributor.author | Couri, Carlos Eduardo Barra | |
dc.contributor.author | Fernandes, Virginia Oliveira | |
dc.contributor.author | Montenegro, Ana Paula Dias Rangel | |
dc.contributor.author | Batista, Livia Aline De Araujo | |
dc.contributor.author | Zajdenverg, Lenita | |
dc.contributor.author | Negrato, Carlos Antonio | |
dc.contributor.author | Malmegrim, Kelen Cristina Ribeiro | |
dc.contributor.author | Moraes, Daniela Aparecida | |
dc.contributor.author | Dias, Juliana Bernardes Elias | |
dc.contributor.author | Oliveira, Maria Carolina | |
dc.contributor.author | Hussain, Akhtar | |
dc.contributor.author | Gomes, Marilia Brito | |
dc.contributor.author | Montenegro, Renan Magalhaes | |
dc.date.accessioned | 2020-06-18T11:27:38Z | |
dc.date.available | 2020-06-18T11:27:38Z | |
dc.date.created | 2020-03-02T14:32:16Z | |
dc.date.issued | 2019 | |
dc.identifier.citation | Penaforte-Saboia, J. G., Couri, C. E. B., Fernandes, V. O., Montenegro, A. P. D. R., Batista, L. A. D. A., Zajdenverg, L., Negrato, C. A., Malmegrim, K. C. R., Moraes, D. A., Dias, J. B. E., Oliveira, M. C., Hussain, A., Gomes, M. B. & Montenegro Jr., R. M. (2019). Lower insulin-dose adjusted A1c (IDAA1c) is associated with less complications in Individuals with Type 1 Diabetes treated with hematopoetic stem-cell transplantation and conventional therapy. Frontiers in Endocrinology, 10: 747. doi: | en_US |
dc.identifier.issn | 1664-2392 | |
dc.identifier.uri | https://hdl.handle.net/11250/2658637 | |
dc.description.abstract | Objective: To evaluate the association between insulin-dose adjusted A1C (IDAA1c) and microvascular complications (MC) and hypoglycemia in a representative Brazilian population of Type 1 diabetes mellitus (T1DM) patients.
Research Design and Methods: This was a cross-sectional study based on a previous study, “Microvascular Complications in Type 1 Diabetes: a comparative analysis of patients treated with autologous nonmyeloablative hematopoietic stem-cell transplantation (AHST) and conventional medical therapy (CT)”. The 168 patients in that study (144 from CT plus 24 from AHST) were re-subdivided into two groups, according to their IDAA1c values (30 patients had IDAA1c ≤ 9; 138 had IDAA1c > 9). Then, the prevalence of MC (diabetic renal disease, neuropathy, and retinopathy), hypoglycemia (blood glucose <60 mg/dL), and severe hypoglycemic (episode of hypoglycemia that required the assistance of another person to treat) events were compared between the groups. The groups were well-matched on these factors: duration of disease, sex, and age at the time of diagnosis of T1DM.
Results: After an average of 8 years after diagnosis, only 6.6% (2/30) of the patients from IDAA1c ≤ 9 group developed any MC, whereas 21.0% (29/138) from the IDAA1c > 9 group had at least one complication (p = 0.044). Regarding hypoglycemic events, the proportion of individuals who reported at least 1 episode of hypoglycemia in the last month was 43.3 and 64.7% from the IDAA1c ≤ 9 and IDAA1c > 9 groups, respectively (p = 0.030). Regarding severe hypoglycemia, the proportion of patients presenting at least one episode in the last month and the rate of episode/patient/month were similar between groups (6.7 vs. 13.2%; p = 0.535; and 0.1/patient/month vs. 0.25/patient/month; p = 0.321).
Conclusion: In a representative Brazilian population of T1DM patients, those with IDAA1c ≤ 9 presented a lower frequency of MC, as well as fewer episodes of hypoglycemia, in the month prior to the analysis. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Frontiers | en_US |
dc.rights | Navngivelse 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/deed.no | * |
dc.title | Lower insulin-dose adjusted A1c (IDAA1c) is associated with less complications in Individuals with Type 1 Diabetes treated with hematopoetic stem-cell transplantation and conventional therapy | en_US |
dc.type | Peer reviewed | en_US |
dc.type | Journal article | en_US |
dc.description.version | publishedVersion | en_US |
dc.rights.holder | © 2019 The Author(s) | en_US |
dc.subject.nsi | VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Endokrinologi: 774 | en_US |
dc.source.pagenumber | 7 | en_US |
dc.source.volume | 10 | en_US |
dc.source.journal | Frontiers in Endocrinology | en_US |
dc.identifier.doi | 10.3389/fendo.2019.00747 | |
dc.identifier.cristin | 1798972 | |