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dc.contributor.authorNedoluzhko, Artem
dc.contributor.authorGruzdeva, Natalia
dc.contributor.authorSharko, Fedor S.
dc.contributor.authorRastorguev, Sergey M
dc.contributor.authorZakharova, Natalia V.
dc.contributor.authorKostyuk, Georgy
dc.contributor.authorUshakov, Vadim
dc.date.accessioned2021-02-17T13:10:06Z
dc.date.available2021-02-17T13:10:06Z
dc.date.created2020-10-05T09:31:23Z
dc.date.issued2020
dc.identifier.citationNedoluzhko, A., Gruzdeva, N., Sharko, F., Rastorguev, S., Zakharova, N., Kostyuk, G. & Ushakov, V. (2020). The Biomarker and Therapeutic Potential of Circular Rnas in Schizophrenia. Cells, 9(10): 2238. doi:en_US
dc.identifier.issn2073-4409
dc.identifier.urihttps://hdl.handle.net/11250/2728696
dc.description.abstractCircular RNAs (circRNAs) are endogenous, single-stranded, most frequently non-coding RNA (ncRNA) molecules that play a significant role in gene expression regulation. Circular RNAs can affect microRNA functionality, interact with RNA-binding proteins (RBPs), translate proteins by themselves, and directly or indirectly modulate gene expression during different cellular processes. The affected expression of circRNAs, as well as their targets, can trigger a cascade of events in the genetic regulatory network causing pathological conditions. Recent studies have shown that altered circular RNA expression patterns could be used as biomarkers in psychiatric diseases, including schizophrenia (SZ); moreover, circular RNAs together with other cell molecules could provide new insight into mechanisms of this disorder. In this review, we focus on the role of circular RNAs in the pathogenesis of SZ and analyze their biomarker and therapeutic potential in this disorder.en_US
dc.language.isoengen_US
dc.publisherMDPIen_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.no*
dc.titleThe Biomarker and Therapeutic Potential of Circular Rnas in Schizophreniaen_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.description.versionpublishedVersionen_US
dc.rights.holder© 2020 The Author(s)en_US
dc.subject.nsiVDP::Matematikk og Naturvitenskap: 400::Basale biofag: 470en_US
dc.subject.nsiVDP::Matematikk og Naturvitenskap: 400::Basale biofag: 470::Molekylærbiologi: 473en_US
dc.source.pagenumber15en_US
dc.source.volume9en_US
dc.source.journalCellsen_US
dc.source.issue10en_US
dc.identifier.doi10.3390/cells9102238
dc.identifier.cristin1836945
dc.relation.projectRussian Scientific Foundation: 20-15-00299en_US
dc.relation.projectRussian Foundation of Basic Research: 18-29-23020 mken_US
dc.relation.projectRussian Foundation of Basic Research: 17-29-02518 ofi-men_US
dc.source.articlenumber2238en_US


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