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dc.contributor.authorKiron, Viswanath
dc.contributor.authorPark, Youngjin
dc.contributor.authorSiriyappagouder, Prabhugouda
dc.contributor.authorDahle, Dalia
dc.contributor.authorVasanth, Ghana Kalerammana
dc.contributor.authorDias, Jorge
dc.contributor.authorFernandes, Jorge Manuel de Oliveira
dc.contributor.authorSørensen, Mette
dc.contributor.authorTrichet, Viviane Verlhac
dc.identifier.citationKiron, V., Park, Y., Siriyappagouder, P., Dahle, D., Vasanth, G. K., Dias, J., Fernandes, J. M. O., Sørensen, M. & Trichet, V. V. (2020). Intestinal transcriptome analysis reveals soy derivative-linked changes in Atlantic salmon. Frontiers in Immunology, 11: 596514. doi:en_US
dc.description.abstractIntestinal inflammation in farmed fish is a non-infectious disease that deserves attention because it is a major issue linked to carnivorous fishes. The current norm is to formulate feeds based on plant-derived substances, and the ingredients that have antinutritional factors are known to cause intestinal inflammation in fishes such as Atlantic salmon. Hence, we studied inflammatory responses in the distal intestine of Atlantic salmon that received a feed rich in soybean derivatives, employing histology, transcriptomic and flow cytometry techniques. The fish fed on soy products had altered intestinal morphology as well as upregulated inflammation-associated genes and aberrated ion transport-linked genes. The enriched pathways for the upregulated genes were among others taurine and hypotaurine metabolism, drug metabolism—cytochrome P450 and steroid biosynthesis. The enriched gene ontology terms belonged to transmembrane transporter- and channel-activities. Furthermore, soybean products altered the immune cell counts; lymphocyte-like cell populations were significantly higher in the whole blood of fish fed soy products than those of control fish. Interestingly, the transcriptome of the head kidney did not reveal any differential gene expression, unlike the observations in the distal intestine. The present study demonstrated that soybean derivatives could evoke marked changes in intestinal transport mechanisms and metabolic pathways, and these responses are likely to have a significant impact on the intestine of Atlantic salmon. Hence, soybean-induced enteritis in Atlantic salmon is an ideal model to investigate the inflammatory responses at the cellular and molecular levels.en_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.titleIntestinal transcriptome analysis reveals soy derivative-linked changes in Atlantic salmonen_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.rights.holder© 2020 The Author(s)en_US
dc.subject.nsiVDP::Landbruks- og Fiskerifag: 900::Fiskerifag: 920::Akvakultur: 922en_US
dc.subject.nsiVDP::Landbruks- og Fiskerifag: 900::Fiskerifag: 920::Fiskehelse: 923en_US
dc.subject.nsiVDP::Matematikk og Naturvitenskap: 400::Basale biofag: 470::Genetikk og genomikk: 474en_US
dc.source.journalFrontiers in Immunologyen_US

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Navngivelse 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Navngivelse 4.0 Internasjonal