dc.contributor.author | Guanglin, Cui | |
dc.contributor.author | Qi, Haili | |
dc.contributor.author | Gundersen, Mona Dixon | |
dc.contributor.author | Yang, Hang | |
dc.contributor.author | Christiansen, Ingrid B | |
dc.contributor.author | Sørbye, Sveinung Wergeland | |
dc.contributor.author | Goll, Rasmus | |
dc.contributor.author | Florholmen, Jon | |
dc.date.accessioned | 2015-02-24T13:44:56Z | |
dc.date.accessioned | 2015-04-23T09:07:51Z | |
dc.date.available | 2015-02-24T13:44:56Z | |
dc.date.available | 2015-04-23T09:07:51Z | |
dc.date.issued | 2014 | |
dc.identifier.citation | Cancer Immunology and Immunotherapy 2014 | |
dc.identifier.issn | 0340-7004 | |
dc.identifier.uri | http://hdl.handle.net/11250/282340 | |
dc.description | - | |
dc.description.abstract | Most sporadic colorectal cancers (CRCs) develop from preformed adenomas. Cytokines are involved in the transition from adenoma to CRC. Interleukin-33 (IL-33) is a newly discovered proinflammatory cytokine belonging to the IL-1 cytokine family and involved in the development of chronic inflammation and cancer. The aim of this study was to evaluate the dynamics of the IL-33/ST2 axis during the sequence of progression from normal colorectum to adenoma to carcinoma and to investigate the association of IL-33 and ST2 expression with clinicopathological parameters and prognosis. The results demonstrated that the levels of IL-33 and ST2 in adenomas (n = 50), determined by real-time PCR, were significantly higher than those of normal controls (n = 30); the levels of both IL-33/ST mRNA in CRCs (n = 50) were higher than in normal controls but lower than in adenomas. Further analysis revealed that the expression level of ST2 in CRCs was associated with tumor/node/metastasis (TNM) stage. The log-rank test showed that neither the IL-33 nor the ST2 expression level was correlated with overall survival in patients with CRC. The increased expression of IL-33/ST2 in adenomas and CRC tissues was confirmed by immunohistochemistry and was observed in both the tumor stromal cells and adenomatous/cancerous cells. Notably, increased densities of IL-33-positive and ST2-positive microvessels were found in the stroma of adenomas and CRCs. In conclusion, increased expression of the IL-33/ST2 axis along the colorectal adenoma–carcinoma sequence might be involved in the neoplastic transformation via the participation of this axis in the regulation of angiogenesis. | |
dc.language.iso | eng | |
dc.relation.uri | http://link.springer.com/article/10.1007%2Fs00262-014-1624-x | |
dc.title | Dynamics of the IL-33/ST2 network in the progression of human colorectal adenoma to sporadic colorectal cancer | |
dc.type | Journal article | |
dc.date.updated | 2015-02-24T13:44:55Z | |
dc.identifier.doi | 10.1007/s00262-014-1624-x | |
dc.identifier.cristin | 1184860 | |