Browsing Nord Open Research Archive by Author "Martens, Dirk E."
Now showing items 1-20 of 22
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Automation of high CHO cell density seed intensification via online control of the cell specific perfusion rate and its impact on the N-stage inoculum quality
Schulze, Markus; Lemke, Johannes; Pollard, David; Wijffels, Rene Hubertus; Matuszczyk, Jens; Martens, Dirk E. (Peer reviewed; Journal article, 2021) -
Bioengineering bacterial outer membrane vesicles as vaccine platform
Gerritzen, Matthias J.H.; Martens, Dirk E.; Wijffels, Rene Hubertus; van der Pol, Leo; Stork, Michiel (Journal article; Peer reviewed, 2017) -
Breakthrough in marine invertebrate cell culture : Sponge cells divide rapidly in improved nutrient medium
Conkling, Megan; Hesp, Kylie; Munroe, Stephanie; Sandoval, Kenneth; Martens, Dirk E.; Sipkema, Detmer; Wijffels, Rene Hubertus; Pomponi, Shirley A. (Peer reviewed; Journal article, 2019)Sponges (Phylum Porifera) are among the oldest Metazoa and considered critical to understanding animal evolution and development. They are also the most prolific source of marine-derived chemicals with pharmaceutical ... -
Continuous production of Neisseria meningitidis outer membrane vesicles
Gerritzen, Matthias J.H.; Stangowez, Lilli; van de Waterbeemd, Bas; Martens, Dirk E.; Wijffels, Rene Hubertus; Stork, Michiel (Peer reviewed; Journal article, 2019)Outer membrane vesicles (OMVs) are nanoparticles secreted by Gram-negative bacteria that can be used for diverse biotechnological applications. Interesting applications have been developed, where OMVs are the basis of drug ... -
CRISPR/Cas12a-mediated gene editing in Geodia barretti sponge cell culture
Hesp, Kylie; Alvarez, John L. Flores; Alexandru, Ana-Maria; van der Linden, Jip; Martens, Dirk E.; Wijffels, Rene Hubertus; Pomponi, Shirley A. (Peer reviewed; Journal article, 2020)Sponges and their associated microorganisms are the most prolific source of marine natural products, and many attempts have been made at creating a marine sponge cell line to produce these products efficiently. However, ... -
Dynamics of triacylglycerol and EPA production in Phaeodactylum tricornutum under nitrogen starvation at different light intensities
Remmers, Ilse M.; Martens, Dirk E.; Wijffels, Rene Hubertus; Lamers, Packo P. (Journal article; Peer reviewed, 2017) -
Evaluation of diurnal responses of Tetradesmus obliquus under nitrogen limitation
Leon-Saiki, G. Mitsue; Carreres, Benoit M.; Remmers, Ilse M.; Wijffels, Rene Hubertus; dos Santos, Vitor A.P. Martins; van der Veen, Douwe; Schaap, Peter J.; Suarez-Diez, Maria; Martens, Dirk E. (Peer reviewed; Journal article, 2020)Tetradesmus obliquus is an oleaginous microalga with high potential for triacylglycerol production. We characterized the biochemical composition and the transcriptional landscape of T. obliquus wild-type and the starchless ... -
Gene silencing of stearoyl-ACP desaturase enhances the stearic acid content in Chlamydomonas reinhardtii
de Jaeger, Lenny; Springer, Jan; Wolbert, Emil J.H.; Martens, Dirk E.; Eggink, Gerrit; Wijffels, Rene Hubertus (Journal article; Peer reviewed, 2017) -
High dissolved oxygen tension triggers outer membrane vesicle formation by Neisseria meningitidis
Gerritzen, Matthias J.H.; Maas, Ronald H.W.; Van Den Ijssel, Jan; Van Keulen, Lonneke; Martens, Dirk E.; Wijffels, Rene Hubertus; Stork, Michiel (Journal article; Peer reviewed, 2018) -
High throughput nanoparticle tracking analysis for monitoring outer membrane vesicle production
Gerritzen, Matthias J.H.; Martens, Dirk E.; Wijffels, Rene Hubertus; Stork, Michiel (Journal article; Peer reviewed, 2017) -
Metabolic characterization of a CHO cell size increase phase in fed-batch cultures
Pan, Xiao; Dalm, Ciska; Wijffels, Rene Hubertus; Martens, Dirk E. (Journal article; Peer reviewed, 2017) -
Neochloris oleoabundans is worth its salt : Transcriptomic analysis under salt and nitrogen stress
de Jaeger, Lenny; Carreres, Benoit M.; Springer, Jan; Schaap, Peter J.; Eggink, Gerrit; Martins dos Santos, Vitor A.P.; Wijffels, Rene Hubertus; Martens, Dirk E. (Journal article; Peer reviewed, 2018) -
Orchestration of transcriptome, proteome and metabolome in the diatom Phaeodactylum tricornutum during nitrogen limitation
Remmers, Ilse M.; D'Adamo, Sarah; Martens, Dirk E.; de Vos, Ric C.H.; Mumm, Roland; America, Antoine H.P.; Cordewener, Jan H.G.; Bakker, Linda V.; Peters, Sander; Wijffels, Rene Hubertus; Lamers, Packo P. (Journal article; Peer reviewed, 2018) -
Prospects for viruses infecting eukaryotic microalgae in biotechnology
D'Adamo, Sarah; Kormelink, Richard; Martens, Dirk E.; Barbosa, Maria J.; Wijffels, Rene Hubertus (Peer reviewed; Journal article, 2021) -
Rapid intensification of an established CHO cell fed-batch process
Schulze, Markus; Niemann, Julia; Wijffels, Rene Hubertus; Matuszczyk, Jens; Martens, Dirk E. (Peer reviewed; Journal article, 2021)Currently, the mammalian biomanufacturing industry explores process intensification (PI) to meet upcoming demands of biotherapeutics while keeping production flexible but, more importantly, as economic as possible. However, ... -
Selection of chemically defined media for CHO cell fed-batch culture processes
Pan, Xiao; Streefland, Mathieu; Dalm, Ciska; Wijffels, Rene Hubertus; Martens, Dirk E. (Journal article; Peer reviewed, 2016) -
Selection of oleaginous yeasts for fatty acid production
Lamers, Dennis; van Biezen, Nick; Martens, Dirk E.; Peters, Linda; van de Zilver, Eric; Jacobs-van Dreumel, Nicole; Wijffels, Rene Hubertus; Lokman, Christien (Journal article; Peer reviewed, 2016) -
Spontaneously released Neisseria meningitidis outer membrane vesicles as vaccine platform : production and purification
Gerritzen, Matthias J.H.; Salverda, Merijn LM; Martens, Dirk E.; Wijffels, Rene Hubertus; Stork, Michiel (Peer reviewed; Journal article, 2019)Outer membrane vesicles (OMVs) are nanoparticles produced by Gram-negative bacteria that can be used as vaccines. The application of OMVs as vaccine component can be expanded by expressing heterologous antigens on OMVs, ... -
Sulfate depletion triggers overproduction of phospholipids and the release of outer membrane vesicles by Neisseria meningitidis
Gerritzen, Matthias J.H.; Martens, Dirk E.; Uittenbogaard, Joost P.; Wijffels, Rene Hubertus; Stork, Michiel (Peer reviewed; Journal article, 2019)Outer membrane vesicles (OMVs) produced by bacteria are interesting vaccine candidates. OMVs are nanoparticles that contain many immunogenic components, are self-adjuvating, and non-replicative. Despite recent insights in ... -
The impact of day length on cell division and efficiency of light use in a starchless mutant of Tetradesmus obliquus
Leon-Saiki, G. Mitsue; Cabrero Marti, Tania; van der Veen, Douwe; Wijffels, Rene Hubertus; Martens, Dirk E. (Journal article; Peer reviewed, 2018)