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dc.contributor.authorVatsos, Ioannis
dc.date.accessioned2017-03-10T08:54:13Z
dc.date.available2017-03-10T08:54:13Z
dc.date.created2016-12-12T09:15:02Z
dc.date.issued2016
dc.identifier.citationVatsos, I. (2016). Standardizing the microbiota of fish used in research. Laboratory Animals, 51(4), 353-364. doi:nb_NO
dc.identifier.issn1758-1117
dc.identifier.urihttp://hdl.handle.net/11250/2433488
dc.descriptionAuthor's accepted version (post-print).nb_NO
dc.description.abstractLittle attention has been paid to the effects of fish microbiotas on the reproducibility and comparability of fish studies so far. Extrinsic and intrinsic factors, such as water quality, environmental microbial populations, diet, host genetic profile, gender, age and stress status, affect fish microbiotas and create significant inter- and intra-species variations. Fish microbiotas play critical roles in many key aspects of host physiology, such as protection against pathogens, digestion and development of the digestive tract and the local immune system. Thus, greater effort should be invested in standardizing the microbiological profiles of research fish. In this context, issues requiring consideration include the establishment of isogenic and isobiotic fish lines, the standardization of rearing conditions and the development of appropriate tests to adequately describe microbial populations. There are many challenges involved in each of these issues, and the research community must decide which aspects should be standardized for each species and each type of research. For all studies in which microbiota is expected to exert an influence, thorough reporting is of paramount importance. Every step towards standardization increases study quality and simultaneously contributes to reducing the number of fish used in research, which is a legal and ethical obligation.nb_NO
dc.language.isoengnb_NO
dc.publisherSAGE Publicationsnb_NO
dc.titleStandardizing the microbiota of fish used in researchnb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.rights.holder© 2016, The Author(s)nb_NO
dc.subject.nsiVDP::Landbruks- og Fiskerifag: 900::Fiskerifag: 920nb_NO
dc.source.pagenumber353-364nb_NO
dc.source.volume51
dc.source.journalLaboratory Animalsnb_NO
dc.source.issue4
dc.identifier.doi10.1177/0023677216678825
dc.identifier.cristin1411218


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