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dc.contributor.authorCui, Guanglin
dc.identifier.citationCui, G. (2019). TH9, TH17, and TH22 cell subsets and their main cytokine products in the pathogenesis of colorectal cancer. Frontiers in Oncology, 9:1002. doi:en_US
dc.description.abstractIn recent years, several newly identified T helper (TH) cell subsets, such as TH9, TH17, and TH22 cells, and their respective cytokine products, IL-9, IL-17, and IL-22, have been reported to play critical roles in the development of chronic inflammation in the colorectum. Since chronic inflammation is a potent driving force for the development of human colorectal cancer (CRC), the contributions of TH9/IL-9, TH17/IL-17, and TH22/IL-22 in the pathogenesis of CRC have recently become an increasingly popular area of scientific investigation. Extensive laboratory and clinical evidence suggests a positive relationship between these new TH subsets and the growth and formation of CRC, whereas, administration of IL-9, IL-17, and IL-22 signaling inhibitors can significantly alter the formation of colorectal chronic inflammation or CRC lesions in animal models, suggesting that blocking these cytokine signals might represent promising immunotherapeutic strategies. This review summarizes recent findings and currently available data for understanding the vital role and therapeutic significance of TH9/IL-9, TH17/IL-17, and TH22/IL-22 in the development of colorectal tumorigenesis.en_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.titleTH9, TH17, and TH22 cell subsets and their main cytokine products in the pathogenesis of colorectal canceren_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.rights.holder© 2019 The Author(s)en_US
dc.subject.nsiVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Onkologi: 762en_US
dc.source.journalFrontiers in Oncologyen_US
dc.relation.projectInnovation Scientists and Technicians Troop Construction Projects of Henan Province: CXTD20150009en_US
dc.relation.projectNature and Science Foundation of Henan Province: 182300410326en_US
dc.relation.projectMedical Research Program, Northern Norway Regional Health Authority: SFP-44-04en_US

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Navngivelse 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Navngivelse 4.0 Internasjonal