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dc.contributor.authorBerenji Ardestani, Simin
dc.contributor.authorEftedal, Ingrid
dc.contributor.authorPedersen, Michael
dc.contributor.authorJeppesen, Per Bendix
dc.contributor.authorNørregaard, Rikke
dc.contributor.authorMatchkov, Vladimir V.
dc.date.accessioned2021-02-03T12:05:09Z
dc.date.available2021-02-03T12:05:09Z
dc.date.created2020-09-01T09:55:45Z
dc.date.issued2020
dc.identifier.citationArdestani, S. B., Eftedal, I., Pedersen, M., Jeppesen, P. B., Nørregaard, R. & Matchkov, V.V. (2020). Endothelial dysfunction in small arteries and early signs of atherosclerosis in ApoE knockout rats. Scientific Reports, 10(1): 15296. doi:en_US
dc.identifier.issn2045-2322
dc.identifier.urihttps://hdl.handle.net/11250/2725983
dc.description.abstractEndothelial dysfunction is recognized as a major contributor to atherosclerosis and has been suggested to be evident far before plaque formation. Endothelial dysfunction in small resistance arteries has been suggested to initiate long before changes in conduit arteries. In this study, we address early changes in endothelial function of atherosclerosis prone rats. Male ApoE knockout (KO) rats (11- to 13-weeks-old) were subjected to either a Western or standard diet. The diet intervention continued for a period of 20-24 weeks. Endothelial function of pulmonary and mesenteric arteries was examined in vitro using an isometric myograph. We found that Western diet decreased the contribution of cyclooxygenase (COX) to control the vascular tone of both pulmonary and mesenteric arteries. These changes were associated with early stage atherosclerosis and elevated level of plasma total cholesterol, LDL and triglyceride in ApoE KO rats. Chondroid-transformed smooth muscle cells, calcifications, macrophages accumulation and foam cells were also observed in the aortic arch from ApoE KO rats fed Western diet. The ApoE KO rats are a new model to study endothelial dysfunction during the earlier stages of atherosclerosis and could help us improve preclinical drug development.en_US
dc.language.isoengen_US
dc.publisherNatureen_US
dc.relation.urihttps://www.nature.com/articles/s41598-020-72338-3
dc.rightsNavngivelse 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.no*
dc.titleEndothelial dysfunction in small arteries and early signs of atherosclerosis in ApoE knockout ratsen_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.description.versionpublishedVersionen_US
dc.rights.holder© 2020 The Author(s)en_US
dc.subject.nsiVDP::Medisinske Fag: 700en_US
dc.source.volume10en_US
dc.source.journalScientific Reportsen_US
dc.source.issue1en_US
dc.identifier.doi10.1038/s41598-020-72338-3
dc.identifier.cristin1826377
dc.relation.projectNorges forskningsråd: 280425en_US
dc.source.articlenumber15296en_US


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