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dc.contributor.authorRamos-Vivas, José
dc.contributor.authorSuperio, Joshua
dc.contributor.authorGalindo-Villegas, Jorge
dc.contributor.authorAcosta, Felix
dc.identifier.citationRamos-Vivas, J., Superio, J., Galindo-Villegas, J. & Acosta, F. (2021). Phage therapy as a focused management strategy in aquaculture. International Journal of Molecular Sciences, 22(19): 10436. doi:en_US
dc.description.abstractTherapeutic bacteriophages, commonly called phages, are a promising potential alternative to antibiotics in the management of bacterial infections of a wide range of organisms including cultured fish. Their natural immunogenicity often induces the modulation of a variated collection of immune responses within several types of immunocytes while promoting specific mechanisms of bacterial clearance. However, to achieve standardized treatments at the practical level and avoid possible side effects in cultivated fish, several improvements in the understanding of their biology and the associated genomes are required. Interestingly, a particular feature with therapeutic potential among all phages is the production of lytic enzymes. The use of such enzymes against human and livestock pathogens has already provided in vitro and in vivo promissory results. So far, the best-understood phages utilized to fight against either Gram-negative or Gram-positive bacterial species in fish culture are mainly restricted to the Myoviridae and Podoviridae, and the Siphoviridae, respectively. However, the current functional use of phages against bacterial pathogens of cultured fish is still in its infancy. Based on the available data, in this review, we summarize the current knowledge about phage, identify gaps, and provide insights into the possible bacterial control strategies they might represent for managing aquaculture-related bacterial diseases.en_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.subjectFish immunologyen_US
dc.titlePhage therapy as a focused management strategy in aquacultureen_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.rights.holder© 2021 The Author(s)en_US
dc.subject.nsiVDP::Klinisk veterinærmedisinske fag: 950en_US
dc.subject.nsiVDP::Landbruks- og Fiskerifag: 900::Fiskerifag: 920::Akvakultur: 922en_US
dc.source.journalInternational Journal of Molecular Sciencesen_US

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Navngivelse 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Navngivelse 4.0 Internasjonal