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dc.contributor.authorNolsøe, Jens M. J.
dc.contributor.authorUnderhaug, Jarl
dc.contributor.authorSørskar, Åshild Moi
dc.contributor.authorAntonsen, Simen Gjelseth
dc.contributor.authorMalterud, Karl E.
dc.contributor.authorGani, Osman
dc.contributor.authorFan, Qiong
dc.contributor.authorHjorth, Marit
dc.contributor.authorSæther, Thomas
dc.contributor.authorHansen, Trond V.
dc.contributor.authorStenstrøm, Yngve H.
dc.identifier.citationNolsøe, J. M. J., Underhaug, J., Sørskar, Å. M., Antonsen, S. G., Malterud, K. E., Gani, O., Fan, Q., Hjorth, M., Sæther, T., Hansen, T. V. & Stenstrøm, Y. H. (2024). Biological evaluations, NMR analyses, molecular modeling studies, and overview of the synthesis of the marine natural product (−)-mucosin. Molecules, 29(5): 994. doi:en_US
dc.description.abstractNatural products obtained from marine organisms continue to be a rich source of novel structural architecture and of importance in drug discovery, medicine, and health. However, the success of such endeavors depends on the exact structural elucidation and access to sufficient material, often by stereoselective total synthesis, of the isolated natural product of interest. (−)-Mucosin (1), a fatty acid derivative, previously presumed to contain a rare cis-bicyclo[4.3.0]non-3-ene moiety, has since been shown to be the trans-congener. Analytically, the fused bicyclic ring system in (−)-1 constitutes a particular challenge in order to establish its relative and absolute stereochemistry. Herein, data from biological evaluations, NMR and molecular modeling studies of (−)-1 are presented. An overview of the synthetic strategies enabling the exact structural elucidation of (−)-mucosin (1) is also presented.en_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.titleBiological evaluations, NMR analyses, molecular modeling studies, and overview of the synthesis of the marine natural product (−)-mucosinen_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.rights.holder© 2024 The Author(s)en_US
dc.relation.projectThe Research Council of Norway: 226244/F50en_US

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Navngivelse 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Navngivelse 4.0 Internasjonal