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dc.contributor.authorDubin, Arseny
dc.contributor.authorJørgensen, Tor Erik
dc.contributor.authorMoum, Truls Borg
dc.contributor.authorJohansen, Steinar Daae
dc.contributor.authorJakt, Lars Martin
dc.identifier.citationDubin, A., Jørgensen, T. E., Moum, T. B., Johansen, S. D. & Jakt, L. M. (2019). Complete loss of the MHC II pathway in an anglerfish, Lophius piscatorius. Biology Letters, 15(10). doi:en_US
dc.description.abstractGenome studies in fish provide evidence for the adaptability of the vertebrate immune system, revealing alternative immune strategies. The reported absence of the major compatibility complex (MHC) class II pathway components in certain species of pipefish (genus Syngnathus) and cod-like fishes (order Gadiformes) is of particular interest. The MHC II pathway is responsible for immunization and defence against extracellular threats through the presentation of exogenous peptides to T helper cells. Here, we demonstrate the absence of all genes encoding MHC II components (CD4, CD74 A/B, and both classical and non-classical MHC II α/β) in the genome of an anglerfish, Lophius piscatorius, indicating loss of the MHC II pathway. By contrast, it has previously been reported that another anglerfish, Antennarius striatus, retains all MHC II genes, placing the loss of MHC II in the Lophius clade to their most recent common ancestor. In the three taxa where MHC II loss has occurred, the gene loss has been restricted to four or five core MHC II components, suggesting that, in teleosts, only these genes have functions that are restricted to the MHC II pathway.en_US
dc.publisherThe Royal Societyen_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.titleComplete loss of the MHC II pathway in an anglerfish, Lophius piscatoriusen_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.rights.holder© The Author(s)en_US
dc.subject.nsiVDP::Matematikk og Naturvitenskap: 400::Basale biofag: 470::Genetikk og genomikk: 474en_US
dc.subject.nsiVDP::Landbruks- og Fiskerifag: 900::Fiskerifag: 920en_US
dc.source.journalBiology Lettersen_US
dc.description.localcodePaid Open Accessen_US

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Navngivelse 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Navngivelse 4.0 Internasjonal