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dc.contributor.authorBirkedal, Ulf
dc.contributor.authorBeckert, Bertrand
dc.contributor.authorWilson, Daniel N.
dc.contributor.authorNielsen, Henrik
dc.identifier.citationBirkedal, U., Beckert, B., Wilson, D. N. & Nielsen, H. (2020). The 23S ribosomal RNA from Pyrococcus furiosus is circularly permuted. Frontiers in Microbiology, 11: 582022. doi:en_US
dc.description.abstractSynthesis and assembly of ribosomal components are fundamental cellular processes and generally well-conserved within the main groups of organisms. Yet, provocative variations to the general schemes exist. We have discovered an unusual processing pathway of pre-rRNA in extreme thermophilic archaea exemplified by Pyrococcus furiosus. The large subunit (LSU) rRNA is produced as a circularly permuted form through circularization followed by excision of Helix 98. As a consequence, the terminal domain VII that comprise the binding site for the signal recognition particle is appended to the 5´ end of the LSU rRNA that instead terminates in Domain VI carrying the Sarcin-Ricin Loop, the primary interaction site with the translational GTPases. To our knowledge, this is the first example of a true post-transcriptional circular permutation of a main functional molecule and the first example of rRNA fragmentation in archaea.en_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.titleThe 23S ribosomal RNA from Pyrococcus furiosus is circularly permuteden_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.rights.holder© 2020 The Author(s)en_US
dc.subject.nsiVDP::Matematikk og Naturvitenskap: 400::Basale biofag: 470::Genetikk og genomikk: 474en_US
dc.subject.nsiVDP::Matematikk og Naturvitenskap: 400::Basale biofag: 470::Generell mikrobiologi: 472en_US
dc.subject.nsiVDP::Matematikk og Naturvitenskap: 400::Basale biofag: 470::Molekylærbiologi: 473en_US
dc.source.journalFrontiers in Microbiologyen_US

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Navngivelse 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Navngivelse 4.0 Internasjonal