dc.contributor.author | Birkedal, Ulf | |
dc.contributor.author | Beckert, Bertrand | |
dc.contributor.author | Wilson, Daniel N. | |
dc.contributor.author | Nielsen, Henrik | |
dc.date.accessioned | 2021-02-25T08:16:50Z | |
dc.date.available | 2021-02-25T08:16:50Z | |
dc.date.created | 2021-02-15T11:11:34Z | |
dc.date.issued | 2020 | |
dc.identifier.citation | Birkedal, U., Beckert, B., Wilson, D. N. & Nielsen, H. (2020). The 23S ribosomal RNA from Pyrococcus furiosus is circularly permuted. Frontiers in Microbiology, 11: 582022. doi: | en_US |
dc.identifier.issn | 1664-302X | |
dc.identifier.uri | https://hdl.handle.net/11250/2730255 | |
dc.description.abstract | Synthesis and assembly of ribosomal components are fundamental cellular processes and generally well-conserved within the main groups of organisms. Yet, provocative variations to the general schemes exist. We have discovered an unusual processing pathway of pre-rRNA in extreme thermophilic archaea exemplified by Pyrococcus furiosus. The large subunit (LSU) rRNA is produced as a circularly permuted form through circularization followed by excision of Helix 98. As a consequence, the terminal domain VII that comprise the binding site for the signal recognition particle is appended to the 5´ end of the LSU rRNA that instead terminates in Domain VI carrying the Sarcin-Ricin Loop, the primary interaction site with the translational GTPases. To our knowledge, this is the first example of a true post-transcriptional circular permutation of a main functional molecule and the first example of rRNA fragmentation in archaea. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Frontiers | en_US |
dc.rights | Navngivelse 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/deed.no | * |
dc.title | The 23S ribosomal RNA from Pyrococcus furiosus is circularly permuted | en_US |
dc.type | Peer reviewed | en_US |
dc.type | Journal article | en_US |
dc.description.version | publishedVersion | en_US |
dc.rights.holder | © 2020 The Author(s) | en_US |
dc.subject.nsi | VDP::Matematikk og Naturvitenskap: 400::Basale biofag: 470::Genetikk og genomikk: 474 | en_US |
dc.subject.nsi | VDP::Matematikk og Naturvitenskap: 400::Basale biofag: 470::Generell mikrobiologi: 472 | en_US |
dc.subject.nsi | VDP::Matematikk og Naturvitenskap: 400::Basale biofag: 470::Molekylærbiologi: 473 | en_US |
dc.source.pagenumber | 11 | en_US |
dc.source.volume | 11 | en_US |
dc.source.journal | Frontiers in Microbiology | en_US |
dc.identifier.doi | 10.3389/fmicb.2020.582022 | |
dc.identifier.cristin | 1889778 | |
dc.source.articlenumber | 582022 | en_US |