Photobiomodulation reduces the cytokine storm syndrome associated with Covid-19 in the zebrafish model
dc.contributor.author | Rosa, Ivana F. | |
dc.contributor.author | Peçanha, Ana Paula B. | |
dc.contributor.author | Carvalho, Tábata R. B. | |
dc.contributor.author | Alexandre, Leonardo S. | |
dc.contributor.author | Ferreira, Vinícius G. | |
dc.contributor.author | Doretto, Lucas B. | |
dc.contributor.author | Souza, Beatriz M. | |
dc.contributor.author | Nakajima, Rafael T. | |
dc.contributor.author | da Silva, Patrick | |
dc.contributor.author | Barbosa, Ana P. | |
dc.contributor.author | Gomes-de-Pontes, Leticia | |
dc.contributor.author | Bomfim, Camila G. | |
dc.contributor.author | Machado-Santelli, Glaucia M. | |
dc.contributor.author | Condino-Neto, Antonio | |
dc.contributor.author | Guzzo, Cristiane R. | |
dc.contributor.author | Peron, Jean P. S. | |
dc.contributor.author | Andrade-Silva, Magaiver | |
dc.contributor.author | Câmara, Niels O. S. | |
dc.contributor.author | Garnique, Anali M. B. | |
dc.contributor.author | Medeiros, Renata J. | |
dc.contributor.author | Ferraris, Fausto K. | |
dc.contributor.author | Barcellos, Leonardo J. G. | |
dc.contributor.author | Correia-Junior, Jose D. | |
dc.contributor.author | Galindo-Villegas, Jorge | |
dc.contributor.author | Machado, Mônica F. R. | |
dc.contributor.author | Castoldi, Angela | |
dc.contributor.author | Oliveira, Susana L. | |
dc.contributor.author | Costa, Camila C. | |
dc.contributor.author | Belo, Marco A. A. | |
dc.contributor.author | Galdino, Giovane | |
dc.contributor.author | Sgro, Germán G. | |
dc.contributor.author | Bueno, Natalia F. | |
dc.contributor.author | Eto, Silas F. | |
dc.contributor.author | Veras, Flávio P. | |
dc.contributor.author | Fernandes, Bianca H. V. | |
dc.contributor.author | Sanches, Paulo R. S. | |
dc.contributor.author | Cilli, Eduardo M. | |
dc.contributor.author | Malafaia, Guilherme | |
dc.contributor.author | Nóbrega, Rafael H. | |
dc.contributor.author | Garcez, Aguinaldo S. | |
dc.contributor.author | Carrilho, Emanuel | |
dc.contributor.author | Charlie-Silva, Ives | |
dc.date.accessioned | 2023-04-11T12:51:01Z | |
dc.date.available | 2023-04-11T12:51:01Z | |
dc.date.created | 2023-03-15T17:23:15Z | |
dc.date.issued | 2023 | |
dc.identifier.citation | Rosa, I. F., Peçanha, A. P. B., Carvalho, T. R. B., Alexandre, L. S., Ferreira, V. G., Doretto, L. B., Souza, B. M., Nakajima, R. T., da Silva, P., Barbosa, A. P., Gomes-de-Pontes, L., Bomfim, C. G., Machado-Santelli, G. M., Condino-Neto, A., Guzzo, C. R., Peron, J. P. S., Andrade-Silva, M., Câmara, Niels O. S., Garnique, A. M. B., ... Charlie-Silva, I. (2023). Photobiomodulation reduces the cytokine storm syndrome associated with Covid-19 in the zebrafish model. International Journal of Molecular Sciences, 24(7), Article 6104. doi: | en_US |
dc.identifier.issn | 1422-0067 | |
dc.identifier.uri | https://hdl.handle.net/11250/3062416 | |
dc.description.abstract | Although the exact mechanism of the pathogenesis of COVID-19 is not fully understood, oxidative stress and the release of pro-inflammatory cytokines have been highlighted as playing a vital role in the pathogenesis of the disease. In this sense, alternative treatments are needed to reduce the inflammation caused by COVID-19. Therefore, this study aimed to investigate the potential effect of red PBM as an attractive therapy to downregulate the cytokine storm caused by COVID-19 from a zebrafish model. RT-PCR analyses and protein-protein interaction prediction among SARS-CoV-2 and Danio rerio proteins showed that rSpike was responsible for generating systemic inflammatory processes with significantly increased pro-inflammatory (il1b, il6, tnfa, and nfkbiab), oxidative stress (romo1) and energy metabolism (slc2a1a, coa1) mRNA markers, with a pattern like those observed in COVID-19 cases in humans. On the other hand, PBM treatment decreased the mRNA levels of these pro-inflammatory and oxidative stress markers compared with rSpike in various tissues, promoting an anti-inflammatory response. Conversely, PBM promotes cellular and tissue repair of injured tissues and significantly increases the survival rate of rSpike-inoculated individuals. Additionally, metabolomics analysis showed that the most impacted metabolic pathways between PBM and the rSpike-treated groups were related to steroid metabolism, immune system, and lipids metabolism. Together, our findings suggest that the inflammatory process is an incisive feature of COVID-19, and red PBM can be used as a novel therapeutic agent for COVID-19 by regulating the inflammatory response. Nevertheless, the need for more clinical trials remains, and there is a significant gap to overcome before clinical trials. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | MDPI | en_US |
dc.rights | Navngivelse 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/deed.no | * |
dc.title | Photobiomodulation reduces the cytokine storm syndrome associated with Covid-19 in the zebrafish model | en_US |
dc.type | Peer reviewed | en_US |
dc.type | Journal article | en_US |
dc.description.version | publishedVersion | en_US |
dc.rights.holder | © 2023 The Authors | en_US |
dc.source.pagenumber | 22 | en_US |
dc.source.volume | 24 | en_US |
dc.source.journal | International Journal of Molecular Sciences | en_US |
dc.source.issue | 7 | en_US |
dc.identifier.doi | 10.3390/ijms24076104 | |
dc.identifier.cristin | 2134238 | |
dc.source.articlenumber | 6104 | en_US |